Novel use of biomimetic aggrecan to regenerate and molecularly repair damaged skin
Throughout the 2015-2016 school year, the senior design team has been focused on injecting various concentrations of biomimetic proteoglycans (BPGs) into porcine skin samples and subsequently characterizing mechanical properties and diffusion behavior. To gauge skin elasticity, they have employed the piezoelectric finger (PEF) method, a technique developed by Dr. Wan Shih of Drexel’s School of Biomedical Engineering, Science and Health Systems. As a means of evaluating diffusion behavior of the BPG solutions, they have cryosectioned and imaged BPG-injected skin samples under the confocal microscope as well as quantified the amount of BPGs at different locations throughout the skin. Their project ultimately aims to assess the potential use of BPGs in future wound healing applications.